Gene expression profie of OSMF (Oral Submucous Fibrosis) tissues compared with the expression in normal oral tissues

ABSTRACT: ABSTRACT: Background: Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral soft tissues. Habit of chewing betel quid has been proposed as an important etiological factor in the development of this disease. But the exact mechanism of pathogenesis is still not clear. Methods: We took microarray approach to identify differentially regulated genes in 10 OSF tissues against 8 pooled normal tissues using oligonucleotide arrays. Microarray results have been confirmed by qRT-PCR. Regulation of genes in epithelial and fibroblast cells was studied after treatment with arecoline, TGF-b and LAP followed by qRT-PCR. Results: Total number of genes found to be commonly regulated in OSF (p<=0.05 and Fold change>=1.5) tissues a

ORGANISM(S): Homo sapiens

SUBMITTER: Paturu Kondaiah 

PROVIDER: E-GEOD-20170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress