Acquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension

ABSTRACT: Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonality and instability of short DNA microsatellite sequences. To assess whether there is larger scale genomic instability, we performed genome-wide microarray copy number analysis on pulmonary artery endothelial (PAEC) and smooth muscle cells isolated from the lungs of PAH patients. Mosaic chromosomal abnormalities were detected in five of nine PAEC cultures from PAH lungs and zero of four controls. Fluorescent in situ hybridization analysis confirmed the presence of these abnormalities in vivo in

ORGANISM(S): Homo sapiens

SUBMITTER: Suzy Comhair 

PROVIDER: E-GEOD-20206 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress