Alterations in the developing testis transcriptome following embryonic vinclozolin exposure

ABSTRACT: The current study investigates the direct effects of in utero vinclozolin exposure on the developing rat testis transcriptome. Vinclozolin is a commonly used fungicide in agriculture and is an endocrine disruptor with anti-androgenic activity. Previous studies have demonstrated that exposure to vinclozolin during embryonic gonadal sex determination induces epigenetic modifications of the germ line and transgenerational adult onset disease states that include spermatogenic cell defects, prostate disease, kidney disease, and tumor development. An investigation of the molecular actions of vinclozolin was initiated through an analysis of direct actions on the F1 generation embryonic testis development. Microarray analyses were performed to compare control and vinclozolin treated testis transcr

ORGANISM(S): Rattus norvegicus

SUBMITTER: Marina Savenkova 

PROVIDER: E-GEOD-20245 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress