Global transcription analysis of immature avian erythrocytic progenitors

ABSTRACT: The molecular mechanisms regulating the cell fate decision between self-renewal and differentiation/apoptosis in stem and progenitor cells are poorly understood. Here, we report the first comprehensive identification of genes potentially involved in the switch from self-renewal toward differentiation of primary, non-immortalized erythroid avian progenitor cells (T2EC cells). We used the Serial Analysis of Gene Expression (SAGE) technique in order to identify and quantify the genome fraction functionally active in a self-renewing versus a differentiating cell population. We generated two SAGE libraries and sequenced a total of 37,589 tags, thereby obtaining the first transcriptional profile characterization of a chicken cell. Tag identification was performed using a new relational database

ORGANISM(S): Gallus gallus

SUBMITTER: Olivier Gandrillon 

PROVIDER: E-GEOD-2026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress