Salivary Transcriptomic and Proteomic Biomarkers for Breast Cancer Detection

ABSTRACT: A sensitive assay to identify biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. In this study, we have conducted a prospective sample collection and retrospective blinded validation (PRoBE design) to evaluate the performance and translational utilities of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. The Affymetrix HG U133 Plus 2.0 Array and 2D-DIGE were used to profile transcriptomes and proteomes in saliva supernatants respectively. Significant variations of salivary transcriptomic and proteomic profiles were observed between breast cancer patients and healthy controls. Eleven transcriptomic biomarker candidates and two proteomic biomarker c

ORGANISM(S): Homo sapiens

SUBMITTER: Hua Xiao 

PROVIDER: E-GEOD-20266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress