Altered gene expression is associated with age-dependent memory impairment

ABSTRACT: The mechanisms underlying age-associated memory impairment are not well understood. We have shown that the onset of memory disturbances in the aging brain is associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation. To analyze if deregulated H4K12 acetylation impacts on learning-induced gene-expression required for memory consolidation we performed a high-density oligonucleotide microarray to compare the entire hippocampal gene-expression profile of 3 and 16-month-old mice during memory consolidation. In order to identify genes differentially regulated between 3- and 16-month old mice upon fear conditioning we subjected 3- and 16-month old mice to fear conditioning (4 mice each group,

ORGANISM(S): Mus musculus

SUBMITTER: Athanasios Zovoilis 

PROVIDER: E-GEOD-20270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress