Systematic meta-analysis and replication of genome-wide expression studies of Parkinson’s disease: 4

ABSTRACT: Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra. Fresh frozen tissue blocks from cerebellar hemispheres of PD patients and controls were provided by the Queens Square Brain Bank for Neurological Disorders (London, UK). Total RNA was isolated from about 500 mg fresh frozen postmortem tissue from each subject by using Trizol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's protocol and further purified using the RNeasy mini kit (Qiagen, Hilden, Germany). Quality of the extracted total RNA was assessed using an Agilent 2100 Bioanalyzer (Agilent Technologies, Boblingen, Germany). Cerebellar mRNA with the following criteria: two distin

ORGANISM(S): Homo sapiens

SUBMITTER: Bin Zheng 

PROVIDER: E-GEOD-20314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress