Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Marjan Boerma
PROVIDER: E-GEOD-2032 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boerma Marjan M van der Wees Caroline G C CG Vrieling Harry H Svensson J Peter JP Wondergem Jan J van der Laarse Arnoud A Mullenders Leon H F LH van Zeeland Albert A AA
BMC genomics 20050118
<h4>Background</h4>During excessive pressure or volume overload, cardiac cells are subjected to increased mechanical stress (MS). We set out to investigate how the stress response of cardiac cells to MS can be compared to genotoxic stresses induced by DNA damaging agents. We chose for this purpose to use ionising radiation (IR), which during mediastinal radiotherapy can result in cardiac tissue remodelling and diminished heart function, and ultraviolet radiation (UV) that in contrast to IR induc ...[more]