The hibernating phenotype assessed through transcript screening

ABSTRACT: Mammalian hibernation is a dramatic physiological transition that involves the controlled reduction of regulated body temperature and the consequent depression of all physiological processes. The resulting reduction of metabolism and associated energy expenditure permits survival during extended periods of poor food availability in winter. To date our understanding of the molecular events that give rise to the hibernating phenotype is fragmentary and incomplete. Here, we present a large-scale gene expression screen to explore the transcriptional changes that are associated with the torpid phenotype of the hibernating golden-mantled ground squirrel, Spermophilus lateralis. Expression profiles for liver, cardiac tissue, and brain isolated from summer active, torpid, and interbout aroused a

ORGANISM(S): Spermophilus lateralis

SUBMITTER: Ruth Taylor 

PROVIDER: E-GEOD-2033 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress