Genomic definition of multiple ex vivo Treg sub-phenotypes

ABSTRACT: Regulatory T (Treg) cells that express the FoxP3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other non-immunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion, or by activation in the presence of TGFβ in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by FoxP3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. Treg cells generated by

ORGANISM(S): Mus musculus

SUBMITTER: Christophe Benoist 

PROVIDER: E-GEOD-20366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress