Expression Profiling of a Genetic Animal Model of Depression

ABSTRACT: Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-like Behaviours In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders Depression Resistant (FRL) lines to understand molecular basis for the differences between the two lines. We profiled two independent cohorts of Flinders animals derived from the same colony six months apart, each cohort statistically powered to allow independent as well as combined analysis. Using this approach, we were able to validate using real-time-PCR a core set of gene expression differences that showed statistical significance in each of the temporally distinct cohorts, rep

ORGANISM(S): Rattus norvegicus

SUBMITTER: Adam Taylor 

PROVIDER: E-GEOD-20388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress