The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome

ABSTRACT: Aging is accompanied by expression changes in multiple genes and the brain is one of the tissues most vulnerable to aging. Since the alpha7 nicotinic acetylcholine receptor (nAChR) subunit has been associated with neurodevelopmental disorders and cognitive decline during aging, we hypothesized that its absence might affect gene expression profiles in aged brains. To study whether transcriptional changes occur due to aging, alpha7 deficiency or both, we analyzed whole brain transcriptomes of young (8 week) and aged (2 year) alpha7 deficient and wild-type control mice, using Mouse Genome 430 2.0 microarray. Highly significant expression changes were detected in 47 and 1543 genes (after Bonferroni and FDR correction) in the brains of aged mice compared to young mice, regardless of their genot

ORGANISM(S): Mus musculus

SUBMITTER: Merav Kedmi 

PROVIDER: E-GEOD-20411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress