HOTAIR transfected Breast Cancer Cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rajnish Gupta
PROVIDER: E-GEOD-20435 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis.
Gupta Rajnish A RA Shah Nilay N Wang Kevin C KC Kim Jeewon J Horlings Hugo M HM Wong David J DJ Tsai Miao-Chih MC Hung Tiffany T Argani Pedram P Rinn John L JL Wang Yulei Y Brzoska Pius P Kong Benjamin B Li Rui R West Robert B RB van de Vijver Marc J MJ Sukumar Saraswati S Chang Howard Y HY
Nature 20100401 7291
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNAs can function as the interface between DNA and specific chromatin remodelling activities. Here we show that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression. The lincRNA termed HOTAIR ...[more]
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