Identification of Aneuploidy-tolerating Mutations

ABSTRACT: Aneuploidy causes a proliferative disadvantage in all cells analyzed to date, yet this condition is associated with a disease characterized by unabated proliferative potential, cancer. The mechanisms that allow cancer cells to tolerate the adverse effects of aneuploidy are not known. To probe this question, we identified aneuploid yeast strains with high proliferative abilities and characterized their genetic alterations. We found both strain-specific genetic alterations and mutations shared between different aneuploid strains. One such mutation, a loss of function mutation in the gene encoding the deubiquitinating enzyme UBP6, improves growth rates in four different aneuploid yeast strains. Our data further suggest that deletion of UBP6 attenuates the effects of aneuploidy on cellular pr

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Cheryl Tucker 

PROVIDER: E-GEOD-20464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress