Comparison of granulosa cells from WT and Inha KO mice following gonadotropin stimulation

ABSTRACT: Inhibin α knockout (Inha-/-) female mice develop sex cord-stromal ovarian cancer with complete penetrance and previous studies demonstrate that the pituitary gonadotropins [follicle stimulating hormone (FSH) and luteinizing hormone (LH)] are influential modifiers of granulosa cell tumor development and progression in inhibin-deficient females. Recent studies have demonstrated that Inha-/- ovarian follicles develop precociously to the early antral stage in prepubertal mice without any increase in serum FSH and these studies suggested that in the absence of inhibins, granulosa cells differentiate abnormally, and thus at sexual maturity may undergo an abnormal response to gonadotropin signaling. To test this hypothesis, we stimulated immature WT and Inha-/- female mice prior to gross tumor fo

ORGANISM(S): Mus musculus

SUBMITTER: Martin Matzuk 

PROVIDER: E-GEOD-20466 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress