RNA profiling in lungs of WT and HGF transgenic mice with or without exposure to carcinogen

ABSTRACT: The hepatocyte growth factor (HGF)/c-Met signaling pathway is known to mediate vascularization. We have previously demonstrated that expression of a human HGF transgene in the small airways produced mice (HGF TG) that were more susceptible to the tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). We also have observed that HGF TG mice display significantly enhanced vascularization in the lungs that increases over time compared to wild-type (WT) littermates. To analyze which genes might contribute to increased vascularization from HGF overexpression in the airways, RNA and protein were isolated from whole lungs of individual HGF TG and WT adult mice. We profiled the mRNA expression of several hundred genes representative of six biological pathways involved in transfor

ORGANISM(S): Mus musculus

SUBMITTER: Jill Siegfried 

PROVIDER: E-GEOD-20468 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress