A single-round of antigen receptor signaling programs naïve B cells to receive T cell help

ABSTRACT: To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single-round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and transcription factor NF-kB activation indistinguishably from conventional continuous IgM cross-linking, but did not induce G1 progression. However, single-round IgM signaling changed the expression of chemokine and chemokine receptor genes implicated in initiating T-dependent responses, as well as accentuated responsiveness to CD40 signaling. Several features of single-round IgM signaling in vitro were recapitulated in B cells after short-term exposure to antigen in vivo. We propose that transient BCR signals prime B cells to

ORGANISM(S): Mus musculus

SUBMITTER: Ranjan Sen 

PROVIDER: E-GEOD-20477 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress