Expression data from (bezafibrate treated-wild type, Clock mutant, and PPARalpha-null) mouse liver

ABSTRACT: A functional interaction between peroxisome proliferator-activated receptor alpha (PPARalpha) and components of the circadian clock has been suggested; however, it remains to be clarified whether those transcriptional factors interact with each other to regulate the expression of their target genes. In this study, we used a ligand of PPARalpha, bezafibrate, to search the PPARalpha-regulated genes that express in a CLOCK-dependent circadian manner. Microarrays analyses using hepatic RNA isolated from bezafibrate treated-wild type, Clock mutant (Clk/Clk), and PPARalpha-null mice revealed that 136 genes are transcriptionally regulated by PPARalpha in a CLOCK-dependent manner. Clk/Clk mutant mice with Jcl:ICR background, wild-type mice with the same strain, and PPARalpha-null mice aged 6-12 we

ORGANISM(S): Mus musculus

SUBMITTER: Katsutaka Oishi 

PROVIDER: E-GEOD-20513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress