Effects of diet and age on canine colon tissue gene expression

ABSTRACT: Aging alters gastrointestinal morphology, microbiota, and functionality, and is associated with increased incidence of intestinal disease. The mechanisms that contribute to these changes are poorly described. Gene expression in dogs has been evaluated for a few select genes under pathogenic or varying dietary conditions, but global gene expression profiles of aged versus young adult dogs have not been compared previously. Thus, we used canine microarrays to compare gene expression profiles of colonic epithelial tissue from geriatric and young adult dogs fed 2 different diets. Colon tissue samples were collected from 6 geriatric (12 yr-old) and 6 young adult (1 yr-old) female beagles after being fed one of two diets (animal protein-based versus plant-protein based) for 12 months. RNA s

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Kelly Swanson 

PROVIDER: E-GEOD-20557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress