Genes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens

ABSTRACT: Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigated the effects of chronic tobacco and alcohol abuse and the interaction of the two behaviours on global gene expression in the human nucleus accumbens using cDNA microarrays and 20 alcoholic and control cases, with and without smoking comorbidity. Changes in gene expression were established by two-way ANOVA. Unsupervised hierarchical clustering was utilized to probe the strength of the data sets. Results: Subjecting the data sets derived from microarray gene expression screening to unsupervis

ORGANISM(S): Homo sapiens

SUBMITTER: Traute Flatscher-Bader 

PROVIDER: E-GEOD-20568 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress