Impact of MAA on mouse Leydig cell gene expression (Mus musculus)

ABSTRACT: Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, an established testicular toxicant. MAA induces the degradation of testicular germ cells in association with changes in gene expression in both germ cells and Sertoli cells of the testis. This study investigates the impact of MAA on gene expression in testicular Leydig cells, which play a critical role in germ cell survival and male reproductive function. Cultured mouse TM3 Leydig cells were treated with MAA for 3, 8, and 24 h and global gene expression was monitored by microarray analysis. A total of 3,912 MAA-responsive genes were identified. Ingenuity Pathway analysis identified reproductive system disease, inflammatory disease and connective tissue disorder as

ORGANISM(S): Mus musculus

SUBMITTER: David Waxman 

PROVIDER: E-GEOD-20625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress