Bone marrow-derived MSC as endometrial stromal progenitor cells

ABSTRACT: In the current study, we hypothesized that if bone-marrow derived MSC contribute to endometrial regeneration and are progenitors to hESF, their treatment with agents known to regulate hESF differentiation could promote their differentiation down the stromal fibroblast lineage. To this end, we treated bone marrow-derived MSC with estradiol (E2) and progesterone (P4), BMP2, and activators of the PKA pathway and investigated specific markers of hESF differentiation (decidualization). Furthermore, we investigated the transcriptome of these cells in response to cAMP and compared this to the transcriptome of hESF decidualized in response to activation of the PKA pathway. The data support that MSC can be differentiated down the hESF pathway, as evidenced by changes in cell shape and common expres

ORGANISM(S): Homo sapiens

SUBMITTER: Lusine Aghajanova 

PROVIDER: E-GEOD-20631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress