Transactivation of the dopamine receptor 3 gene results in development of B-cell lymphoma in mice

ABSTRACT: Transactivation of the dopamine receptor 3 gene by a single provirus integration results in development of B-cell lymphoma in transgenic mice generated from retrovirally transduced embryonic stem cells. Gene transfer vectors based on retroviruses are commonly used in gene therapy applications because of their unique ability to integrate efficiently into host genomes. This ability also forms the basis of a transformation event that can be induced in transduced cells by transactivation of proto-oncogenes near the vector integration sites. Here, we report on the development of lymphoma in mice generated from embryonic stem cells transduced with an enhanced green fluorescent protein. The cells expressed B220, CD5, Mac1, and IgM on their surfaces and expressed transcription factors characteris

ORGANISM(S): Mus musculus

SUBMITTER: MASAFUMI ONODERA 

PROVIDER: E-GEOD-20661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress