Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Geo Semini
PROVIDER: E-GEOD-20722 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pharmacogenetics and genomics 20110701 7
<h4>Objective</h4>New alkylphospholipids (APLs) that are structurally derived from the platelet-activating factor (PAF) are promising candidates for anticancer treatment. After incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion, and apoptosis. In addition to the prototype 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine), we presented a novel group of APLs, the glycosidated phospholipids ...[more]