Gene expression signatures for human iPS cell lines

ABSTRACT: The reprogramming of human fibroblasts to generate induced pluripotent stem cells (hiPSCs) has been achieved through the expression of only a few exotic factors1-8, which is morphologically and molecularly verified in outer cellular states by characteristic markers, due to the remodeling of the somatic cell transcription programs in inner cellular states to the ES-like condition. Transcription factor-induced reprogramming to self-renewal and pluripotency raises the question as to how the exotic factors act to bring about these changes in the two cellular states9-11. Here, we applied RNA profiling to uncover gene expression changes and glycan profiling12 to survey structural changes in glycans, to compare hiPSCs and parental somatic cells, in total 51 cells, which were originally cultured a

ORGANISM(S): Homo sapiens

SUBMITTER: Makoto Asashima 

PROVIDER: E-GEOD-20750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress