Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Short-term (12h) ATRA treatment of embryoid bodies.

ABSTRACT: We used microarrays to detail the global programme of gene expression in embryonic stem cells, early differentiated embrioid bodies and effect of short-term ATRA treatment. Expression data from undifferentiated mouse embryonic stem cells (D3), four-day old aggregated embrioid bodies and 12h atRA or DMSO treated embrioid bodies. Three replicates each.

ORGANISM(S): Mus musculus

SUBMITTER: Zoltan Simandi 

PROVIDER: E-GEOD-20919 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodies.

Simandi Zoltan Z   Balint Balint Laszlo BL   Poliska Szilard S   Ruhl Ralph R   Nagy Laszlo L  

FEBS letters 20100602 14

Retinoid signaling has been implicated in embryonic stem cell differentiation. Here we present a systematic analysis of gene expression changes in mouse embryonic stem cells (mESCs), during their spontaneous differentiation into embryoid bodies and the effect of all-trans retinoic acid (ATRA) on this process. We show that retinoic acid is present in the serum and is sufficient to activate retinoid signaling at a basal level in undifferentiated mESCs. This signal disappears during embryoid body f  ...[more]

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