Gene expression profiles of irradiated lung tissue in three mouse strains

ABSTRACT: The aim of our research is to clarify the mechanisms generating heterogeneity in response to C-ion irradiation that arise from individual genetic variations in humans. In this study, we performed whole lung C-ion irradiation using three different strains of mice to examine whether strain-dependent differences in radiation effects occur in high-LET C-ion thoracic irradiation. Murine strain-variance was evaluated by histopathological examination of intra-alveolar hemorrhage that is likely to occur during the early phase after irradiation, and of lung fibrosis during the late phase, occurring more than three months after irradiation. We also performed microarray analysis to identify the key genes that are differentially regulated in different mouse strains after C-ion irradiation and to deter

ORGANISM(S): Mus musculus

SUBMITTER: Kaori Imadome 

PROVIDER: E-GEOD-20959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress