SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH

ABSTRACT: Many studies estimate that chromosomal mosaicism within the cleavage stage human embryo is high. However, comparison of two unique methods of aneuploidy screening of blastomeres within the same embryo has not been conducted and may indicate whether mosaicism is overestimated due to technical inconsistency rather than biological phenomena. The present study investigates the prevalence of chromosomal abnormality and mosaicism found with two different single cell aneuploidy screening techniques.Thirteen arrested cleavage stage embryos were studied. Each was biopsied into individual cells (n=160). The cells from each embryo were randomized into two groups. Those destined for FISH based aneuploidy screening (n=75) were fixed, 1 cell per slide. Cells for SNP microarray based aneuploidy screeni

ORGANISM(S): Homo sapiens

SUBMITTER: Nathan Treff 

PROVIDER: E-GEOD-20975 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress