Gene expression profile analysis in the mid-gestation human intestine discloses greater immaturity of the colon as compared to ileum

ABSTRACT: The occurrence of many neonatal inflammatory intestinal diseases in preterm infants highlights the susceptibility of the immature intestine to respond inadequately to nutrient and microbes. A better understanding of the functional intestinal development is essential for the design of optimal treatments ensuring survival and growth of premature infants. The purpose of this study was to evaluate the gene expression profiles of the developing human ileum and colon at mid-gestation. Our results showed that more than 11% of the genes were differentially expressed between ileum and colon. Pathway analysis revealed an even higher level of transcriptional dissimilarity between the developing ileum and the colon including 35% of the significant cellular, molecular and physiological functions and 85

ORGANISM(S): Homo sapiens

SUBMITTER: Jean-François Beaulieu 

PROVIDER: E-GEOD-20983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress