Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

ABSTRACT: We investigated the Prkar1a+/- mice when bred with Prkaca+/- genetic backgrounds. Prkar1a+/-Prkaca+/- mice not only continued to develop bone lesions but also demonstrated a significant increase in both the number and the severity of the lesions, as well as a reduction in the age of first appearance of any bone abnormality. Histological analysis of bone from Prkar1a+/-Prkaca+/- mice showed that lesions had similarity to tumors from humans with CNC and some resemblance (but also differences) from humans and mice with fibrous dysplasia (FD). Prkar1a+/- and Prkar1a+/-Prkaca+/- mouse lesions always involved a particular sub-population of cells that could be identified as belonging to the osteoblastic lineage, that were initially located on the endosteal surface of the periosteum and nearby tr

ORGANISM(S): Mus musculus

SUBMITTER: C Cheadle 

PROVIDER: E-GEOD-20984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress