Comparison of gene expression in CD13 wild type versus Knock out Macrophages

ABSTRACT: The robust and consistent expression of the CD13 cell surface marker on very early as well as differentiated myeloid hematopoietic cells has prompted numerous investigations seeking to define roles for CD13 in myeloid cells. To directly address the function of myeloid CD13 we created a CD13 null mouse and assessed the responses of purified primary macrophages or dendritic cells from wild type and CD13 null animals in cell assays and inflammatory disease models where CD13 has been previously implicated. We find that mice lacking CD13 develop normally with normal hematopoietic profiles. Moreover, in in vitro assays, CD13 appears to be largely dispensable for the aspects of phagocytosis, proliferation and antigen presentation that we tested, but may contribute to adhesion to endothelial ce

ORGANISM(S): Mus musculus

SUBMITTER: Anupinder Kaur 

PROVIDER: E-GEOD-20985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress