Next-generation sequencing identifies the natural killer cell microRNA transcriptome

ABSTRACT: Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g. granzyme B, GzmB) through unclear molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate the translation of their mRNA targets, and are therefore candidates mediating this control process. While the expression and importance of miRNAs in T and B lymphocytes has been established, little is known about miRNAs in NK cells. Here, we utilized two next-generation sequencing (NGS) platforms to define the miRNA transcriptomes of resting and cytokine-activated primary murine NK cells, with confirmation by RT

ORGANISM(S): Mus musculus

SUBMITTER: Seth Crosby 

PROVIDER: E-GEOD-21003 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress