Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: fluoranthene

ABSTRACT: Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene expression following exposure to fluoranthene (FA). DEBtox modelling showed an effect of FA on costs for growth and reproduction (i.e. for production of new and differentiated biomass). The microarray analysis supported this effect, showing an effect of FA on protein integrity and turnover that would be expected to have consequences for rates of somatic growth. Our results have established that outputs from process based models and transcriptomics analyses can help to link mechanisms of action of to

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Martijs Jonker 

PROVIDER: E-GEOD-21011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress