DNA microarrays of SKOM transduced MEFs with added Tgfb1 or co-expressing Snail

ABSTRACT: The Tgf-b signaling pathway plays an important role in both embryonic development and epithelial to mesenchymal transition (EMT), but the influence of this pathway and its relationship with EMT in fibroblast reprogramming is not defined. Using Affymetrix mouse genome array and mouse embryonic fibroblast cells (MEFs), we analyzed the expression profiles of Tgf-b1 and one of its important mediators in EMT, Snail, regulated genes at Day 10 during the process of reprogramming. A total of 535 genes were differentially expressed (2-fold change) in cells activated by Tgf-b1 and 970 genes were differentially expressed in cells over-expressing Snail. Among them, 170 genes were shared in both categories. The differentially expressed genes involve in many biological processes, including Tgf-b signali

ORGANISM(S): Mus musculus

SUBMITTER: Duanqing Pei 

PROVIDER: E-GEOD-21064 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress