Sex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm

ABSTRACT: Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profiles. Mice were infected with C. burnetii for 24 hours, and gene expression was measured in liver cells using microarrays. Multiclass analysis identified 2,777 probes for which expression was specifically modulated by C. burnetti infection. Only 14% of the modulated genes were sex-independent, and the remaining 86% were differentially expressed in males and females. Castration of males and females showed that sex hormones were responsible for more than 60% of the observed gene modulation, and this

ORGANISM(S): Mus musculus

SUBMITTER: Didier Raoult 

PROVIDER: E-GEOD-21065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress