Transcription profiling of human bone marrow-derived sesenchymal stem cells with prolonged life span vs life span after neuronal induction
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Akihiro Umezawa
PROVIDER: E-GEOD-2110 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential.
Mori Taisuke T Kiyono Tohru T Imabayashi Hideaki H Takeda Yukiji Y Tsuchiya Kohei K Miyoshi Shunichirou S Makino Hatsune H Matsumoto Kenji K Saito Hirohisa H Ogawa Satoshi S Sakamoto Michiie M Hata Jun-Ichi J Umezawa Akihiro A
Molecular and cellular biology 20050601 12
Murine bone marrow stromal cells differentiate not only into mesodermal derivatives, such as osteocytes, chondrocytes, adipocytes, skeletal myocytes, and cardiomyocytes, but also into neuroectodermal cells in vitro. Human bone marrow stromal cells are easy to isolate but difficult to study because of their limited life span. To overcome this problem, we attempted to prolong the life span of bone marrow stromal cells and investigated whether bone marrow stromal cells modified with bmi-1, hTERT, E ...[more]
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