Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Barry Taylor
PROVIDER: E-GEOD-21124 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.
Barretina Jordi J Taylor Barry S BS Banerji Shantanu S Ramos Alexis H AH Lagos-Quintana Mariana M Decarolis Penelope L PL Shah Kinjal K Socci Nicholas D ND Weir Barbara A BA Ho Alan A Chiang Derek Y DY Reva Boris B Mermel Craig H CH Getz Gad G Antipin Yevgenyi Y Beroukhim Rameen R Major John E JE Hatton Charles C Nicoletti Richard R Hanna Megan M Sharpe Ted T Fennell Tim J TJ Cibulskis Kristian K Onofrio Robert C RC Saito Tsuyoshi T Shukla Neerav N Lau Christopher C Nelander Sven S Silver Serena J SJ Sougnez Carrie C Viale Agnes A Winckler Wendy W Maki Robert G RG Garraway Levi A LA Lash Alex A Greulich Heidi H Root David E DE Sellers William R WR Schwartz Gary K GK Antonescu Cristina R CR Lander Eric S ES Varmus Harold E HE Ladanyi Marc M Sander Chris C Meyerson Matthew M Singer Samuel S
Nature genetics 20100704 8
Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States, show remarkable histologic diversity, with more than 50 recognized subtypes. However, knowledge of their genomic alterations is limited. We describe an integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes. Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8 ...[more]
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