Gene Expression Profiles in BA46 of Subjects with Schizophrenia and Matched Controls

ABSTRACT: Results from clinical and imaging studies provide evidence for changes in schizophrenia with disease progression, however, the underlying molecular differences that may occur at different stages of illness have not been investigated. To test the hypothesis that the molecular basis for schizophrenia changes from early to chronic illness, we profiled genome-wide expression patterns in prefrontal cortex of schizophrenic subjects at different stages of illness, along with their age- and sex-matched controls. Results show that gene expression profiles change dramatically depending on the stage of illness, whereby the greatest number and magnitude of gene expression differences were detected in subjects with short-term illness (â?¤ 4 years from diagnosis). Comprehensive pathways analyses re

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Thomas 

PROVIDER: E-GEOD-21138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress