Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Haoqiang Ying
PROVIDER: E-GEOD-21143 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zheng Hongwu H Ying Haoqiang H Wiedemeyer Ruprecht R Yan Haiyan H Quayle Steven N SN Ivanova Elena V EV Paik Ji-Hye JH Zhang Hailei H Xiao Yonghong Y Perry Samuel R SR Hu Jian J Vinjamoori Anant A Gan Boyi B Sahin Ergun E Chheda Milan G MG Brennan Cameron C Wang Y Alan YA Hahn William C WC Chin Lynda L DePinho Ronald A RA
Cancer cell 20100501 5
A hallmark feature of glioblastoma is its strong self-renewal potential and immature differentiation state, which contributes to its plasticity and therapeutic resistance. Here, integrated genomic and biological analyses identified PLAGL2 as a potent protooncogene targeted for amplification/gain in malignant gliomas. Enhanced PLAGL2 expression strongly suppresses neural stem cell (NSC) and glioma-initiating cell differentiation while promoting their self-renewal capacity upon differentiation ind ...[more]