Mycobacterium bovis-BCG vaccination induces a specific pulmonary transcriptome biosignature in mice

ABSTRACT: In the present study, we applied microarray technology to define a biosignature from the whole genome expression in lung and spleen samples after BCG vaccination and M. bovis infection of BALB/c mice. The aims were two-fold, namely to define biosignatures that could predict vaccine success before challenge, and biomarker patterns that correlated with anamnestic protective responses following exposure to virulent M. bovis. Further, Our aim was to define these markers to be detectable without in vitro antigenic challenge. After BCG vaccination, we defined a specific pulmonary gene expression signature related to the connective tissue development and function network that predicted vaccine success before M. bovis challenge. In addition, a Th17-related cytokine profile was found that correlate

ORGANISM(S): Mus musculus

SUBMITTER: Martin Vordermeier 

PROVIDER: E-GEOD-21149 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress