Investigations of gene expression in fathead minnow (Pimephales promelas) brain tissue reveal toxicological impacts of RDX exposure

ABSTRACT: Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) function in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). A brain-tissue based cDNA library enriched for transcripts differentially expressed in response to RDX exposure was developed for fathead minnow and was transitioned to custom cDNA-based microarrays. All 4,128 cDNAs were sequenced

ORGANISM(S): Pimephales promelas

SUBMITTER: Kurt Gust 

PROVIDER: E-GEOD-21153 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress