Systems Biology Analysis of Zymomonas mobilis ZM4 Ethanol Stress Responses

ABSTRACT: Background Zymomonas mobilis ZM4 is a capable ethanologenic bacterium with high ethanol productivity and ethanol tolerance. Previous studies indicated that several stress-related proteins and changes in the ZM4 membrane lipid composition may contribute to ethanol tolerance. However, the molecular mechanisms of its ethanol stress response have not been elucidated fully. Methodology/Principal Findings In this study, ethanol stress responses were investigated using systems biology approaches. Medium supplementation with an initial 47 g/L (6% v/v) ethanol reduced Z. mobilis ZM4 glucose consumption, growth rate and ethanol productivity compared to that of untreated controls. A proteomic analysis of early exponential growth identified about one thousand proteins, or approximately 55% of the p

ORGANISM(S): Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821

SUBMITTER: Shihui YANG 

PROVIDER: E-GEOD-21165 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress