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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human CALM-AF10 positive and negative T-ALL samples

ABSTRACT: Comparison of a series of 6 CALM-AF10 positive T-ALL to a series of 17 CALM-AF10 negative T-ALL

ORGANISM(S): Homo sapiens

SUBMITTER: Eric DELABESSE

PROVIDER: E-GEOD-2117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.

Dik W A WA Brahim W W Braun C C Asnafi V V Dastugue N N Bernard O A OA van Dongen J J M JJ Langerak A W AW Macintyre E A EA Delabesse E E

Leukemia 20051101 11

The t(10;11)(p13;q14-21) is found in T-ALL and acute myeloid leukemia and fuses CALM (Clathrin-Assembly protein-like Lymphoid-Myeloid leukaemia gene) to AF10. In order to gain insight into the transcriptional consequences of this fusion, microarray-based comparison of CALM-AF10+ vs CALM-AF10- T-ALL was performed. This analysis showed upregulation of HOXA5, HOXA9, HOXA10 and BMI1 in the CALM-AF10+ cases. Microarray results were validated by quantitative RT-PCR on an independent group of T-ALL and ...[more]

PMID: 16107895

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Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA)

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