Generation of Induced Pluripotent Stem Cells from Human Testis Biopsy Derived Fibroblastic Cells

ABSTRACT: Although reported more than once, the generation of pluripotent stem cell populations from human testis remains questionable. We recently showed that the so - called human adult germline stem cells (haGSCs), which were claimed to be pluripotent, showed a gene expression profile comparable to human fibroblasts, suggesting that these cells are originated from a fibroblastic cells. We could derive human testicular fibroblast cells (hTFCs) from several routine testicular biopsies, naming them human testicular fibroblastic cells (hTFCs). The true conversion of unipotent mouse GSCs, also known as spermatogonial stem cells into pluripotent stem cells was recently shown. However, this conversion was not observed for human cells so far. We suggest that hTFCs isolated from routine biopsies can help

ORGANISM(S): Homo sapiens

SUBMITTER: Marcos Araúzo-Bravo 

PROVIDER: E-GEOD-21179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress