Transcription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation

ABSTRACT: The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a master regulator of this network when the inducing DNA lesions are double strand breaks. The ATM gene is also frequently mutated in sporadic cancers of lymphoid origin. Here, we applied a functional genomics approach that combines gene expression profiling and computational promoter analysis to obtain global dissection of the transcriptional response to ionizing radiation (IR) in murine lymphoid tissue. Cluster analysis revealed six major expression patterns in the data. Prominent among them was a ge

ORGANISM(S): Mus musculus

SUBMITTER: Ran Elkon 

PROVIDER: E-GEOD-2118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress