Characterization of the small RNA population in Human spermatozoa

ABSTRACT: Small noncoding RNAs (sncRNA) are becoming recognized for their participation in a diverse range of cellular functions. In this study, their global characterization in human spermatozoa from donors with proven fertility was undertaken. Reads were analyzed in two classes, those mapping to unique locations and those that could be aligned to up to 10 genomic locations. All libraries showed comparable distribution of reads between intergenic, intronic and exonic genomic regions. Analysis of the sequences revealed the presence of multiple small RNA classes. The miRNAs retained in spermatozoa were found to be associated with promoter regions, suggestive of a role at the transcriptional level. Piwi-interacting sncRNAs as well as repeat-associated small RNAs were identified for the first time

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Krawetz 

PROVIDER: E-GEOD-21191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress