CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data]

ABSTRACT: Transcription factors that bind small DNA motifs embedded in promoters play a central role in controlling gene expression. However, in addition to these elements, up to 70% of genes in higher eukaryotes also have high levels of non-methylated cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units. These features, called CpG islands, were identified over twenty years ago but there remains little mechanistic evidence to suggest how these enigmatic elements contribute to promoter function, with the exception that they are refractory to epigenetic silencing by DNA methylation. Here we show that CpG islands directly recruit the H3K36 specific lysine demethylase enzyme KDM2A. Genome wide analyses by ChIP-seq demonstrated a striking global association of KDM2A with CpG

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Park 

PROVIDER: E-GEOD-21201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress