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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse lymph nodes treated with soluble lymphotoxin-beta receptor for 0, 1, 2, 3, 27 and 35 days

ABSTRACT: treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Huber

PROVIDER: E-GEOD-2124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes.

Huber Christoph C Thielen Caroline C Seeger Harald H Schwarz Petra P Montrasio Fabio F Wilson Mark R MR Heinen Ernst E Fu Yang-Xin YX Miele Gino G Aguzzi Adriano A

Journal of immunology (Baltimore, Md. : 1950) 20050501 9

Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT beta receptor (LTbetaR) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expr ...[more]

PMID: 15843551

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sLTbetaR-Ig treated mLN

Project description:treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days Keywords: time-course

2005-03-04 | GSE2124 | GEO

scRNAseq of stromal cells isolated from mesenteric lymph nodes (MLN), peripheral lymph nodes (PLN) and mandibular lymph nodes (mandLN)

Project description:scRNAseq of stromal cells isolated from mesenteric lymph nodes (MLN), peripheral lymph nodes (PLN) and mandibular lymph nodes (mandLN)

2022-09-01 | E-MTAB-11644 | biostudies-arrayexpress

Expression data from pig mesenteric lymph nodes

2010-06-11 | GSE22311 | GEO

Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.

Project description: Not available

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Expression data from pig mesenteric lymph nodes

Project description:The mesenteric lymph nodes represent the immune response to eggs in schistosome infections,and the analysis of gene expression profiles of the mesenteric lymph nodes from the Vac-Cha (vaccinated with UV attenuated cercariae and challenged with normal cercariae)and Inf-Con (infected with normal cercariae) groups. We used microarrays to detail the global programme of gene expression and identified distinct classes of up-regulated and down-regulated genes. The mesenteric lymph nodes surrounding the cecum from the Vac-Cha and Inf-Con groups were collected at week 8 post challenge and used to analyze the gene profile with Affymetrix microarrays. We sought to obtain the different genes expression profiles between the Vac-Cha group and Inf-Con group.The Vac-Cha group is three pigs vaccinated with UV attenuated Schistosoma japonicum cercariae and challenged with normal Schistosoma japonicum cercariae, and the Inf-Con group is three pigs infected with normal cercariae. Samples pooled per group. A list of differentially-regulated genes can be found in the supplementary file below.

2010-06-23 | E-GEOD-22311 | biostudies-arrayexpress

RNA seq for CD4 T cells in lymph nodes from rhesus macaques

Project description:We evaluated transcriptional profiling of CD4 T cells from mesenteric and genital lymph nodes following SIV infection by RNA-seq.

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Expression data from non-infected and Salmonella Choleraesuis infected mesenteric lymph nodes

Project description:To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. Choleraesuis infection, and to characterize the global host responses by revealing the specific features of the host’s innate immunity. Keywords: time course

2007-09-30 | GSE7314 | GEO

Analyses of ILC3s from the mesenteric lymph nodes (LN)

Project description:Analyses of ILC3s in Rorc floxed control and Id2iÎ?RORÎ³t mice following daily treatments of tamoxifen for two weeks. Cells were sort purified as lineage negative, CD127+ CD90.2+ CCR6+ ST2- CCR6+ ILCs were sorted from the mesenteric LN of Rorc floxed control and Id2iÎ?RORÎ³t mice following daily treatments of tamoxifen for two weeks.

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Early Life Programming of Mesenteric Lymph Node Stromal Cell Identity by the Lymphotoxin Pathway Regulates Mucosal Immune Responses in the Adult (Stromal cells)

Project description:Redundant mechanisms support IgA responses to intestinal antigens. These include multiple priming sites (mesenteric lymph nodes (MLN), Peyer's patches and isolated lymphoid follicles) and various cytokines that promote class switch to IgA, even in the absence of T cells. In spite of these back-up mechanisms, vaccination against enteric pathogens such as Rotavirus has limited success in some populations.Genetic and environmental signals experienced during early life are known to influence mucosal immunity, yet the mechanisms for how these exposures operate remain unclear. Here we used Rotavirus infection to follow antigen-specific IgA responses through time and in different gut compartments. Using genetic and pharmacological approaches, we tested the role of a pathway known to support IgA responses (Lymphotoxin - LT) at different developmental stages. We found that LT-beta receptor (LTβR) signalling in early life programs intestinal IgA responses in adulthood by affecting antibody class switch recombination to IgA and subsequent generation of IgA antibody-secreting cells within an intact MLN. In addition, early life LTβR signalling dictates the phenotype and function of MLN stromal cells in order to support IgA responses in the adult. Collectively, our studies uncover new mechanistic insights into how early life LTβR signalling impacts mucosal immune responses during adulthood.

2019-10-05 | GSE138456 | GEO

Early Life Programming of Mesenteric Lymph Node Stromal Cell Identity by the Lymphotoxin Pathway Regulates Mucosal Immune Responses in the Adult (B cells)

2019-10-05 | GSE138455 | GEO

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