High-resolution aCGH analyses of copy number alterations in HER2-amplified breast cancer
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Åke Borg
PROVIDER: E-GEOD-21259 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
Staaf Johan J Jönsson Göran G Ringnér Markus M Vallon-Christersson Johan J Grabau Dorthe D Arason Adalgeir A Gunnarsson Haukur H Agnarsson Bjarni A BA Malmström Per-Olof PO Johannsson Oskar Th OT Loman Niklas N Barkardottir Rosa B RB Borg Ake A
Breast cancer research : BCR 20100506 3
<h4>Introduction</h4>HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in all molecular subtypes and represent a genomically and biologically heterogeneous group, needed to be further characterized in large sample sets.<h4>Methods</h4>Genome-wide DNA c ...[more]
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