High-resolution aCGH analyses of copy number alterations in HER2-amplified breast cancer

ABSTRACT: HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in all molecular subtypes and represent a genomically and biologically heterogeneous group. Genome-wide DNA copy number profiling, using BAC array comparative genomic hybridization (aCGH) were performed on 200 tumors with mixed clinical characteristics and amplification of HER2. Genomic Identification of Significant Targets in Cancer (GISTIC) was used to identify significant copy number aberrations (CNAs) in HER2+ tumors. This analysis sheds further light on the genomically complex and heterogene

ORGANISM(S): Homo sapiens

SUBMITTER: Åke Borg 

PROVIDER: E-GEOD-21259 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress