Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training

ABSTRACT: Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of genes that were differentially expressed following a ten month period of exercise training. The study cohort comprised 7 thoroughbred racehorses from a single training yard. Skeletal muscle biopsies were collected at rest from the gluteus medius at two time points: T1 (unconditioned), (9 +/- 0.5 months old) and T2 (conditioned) (20 +/- 0.7 months old). The most highly abundant genes in the muscle transcriptome were those involved in muscle contraction, aerobic respiration and mitochondrial function. A previously unreported over-representation of genes relating to RNA processing, the stress response and proteolysis was observed. Following trainin

ORGANISM(S): Equus caballus

SUBMITTER: Paul McGettigan 

PROVIDER: E-GEOD-21269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress